منابع مشابه
Protein Phosphatases Targeted Library
Preamble Phosphatases constitute a wide class of enzymes which remove a phosphate group from the target substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. This action is directly opposite to that of phosphorylases and kinases. While kinases phosphorylate cellular substrates by using energetic molecules like ATP, phosphatases, in t...
متن کاملMetaplastic protein phosphatases.
Activity-dependent synaptic plasticity is widely considered to be one of the cellular mechanisms that underlie learning and memory. Long-term potentiation (LTP) is the most intensely studied form of synaptic plasticity, in part because it can be induced at glutamatergic synapses in the mammalian brain, including the hippocampus, a structure known for its involvement in memory function. LTP can ...
متن کاملPhosphotyrosyl protein phosphatases.
Enzyme-catalysed reversible protein phosphorylation is an important cellular regulatory mechanism (Nimmo & Cohen, 1977; Krebs & Beavo, 1979). Regulatory protein phosphorylation occurs most frequently on seryl and threonyl residues (Taborsky, 1974), and less frequently, on tyrosyl residues (Hunter, 1982). Protein phosphotyrosine [Tyr(P)] normally accounts for only 0.01-0.050o of the total protei...
متن کاملTrypanosomatid protein phosphatases
Protein phosphorylation is one of the most important post-translational modifications regulating various signaling processes in all known living organisms. In the cell, protein phosphatases and protein kinases play a dynamic antagonistic role, controlling the phosphorylation state of tyrosine (Tyr), serine (Ser) and threonine (Thr) side chains of proteins. The reversible phosphorylation modulat...
متن کاملPlant Protein Phosphatases.
Posttranslational modification of proteins by phosphorylation is a universal mechanism for regulating diverse biological functions. Recognition that many cellular proteins are reversibly phosphorylated in response to external stimuli or intracellular signals has generated an ongoing interest in identifying and characterizing plant protein kinases and protein phosphatases that modulate the phosp...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1997
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.8.504